手性放大与立体动态三芳基探针：手性醇的绝对构型和对映体过量的确定。
Chiral amplification with a stereodynamic triaryl probe: assignment of the absolute configuration and enantiomeric excess of amino alcohols.
机构信息
Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
出版信息
J Am Chem Soc. 2009 Nov 18;131(45):16360-1. doi: 10.1021/ja907741v.
PMID:19902975
Abstract
A stereodynamic, axially chiral triaryl probe is locked into a single conformation upon condensation with two amino alcohol substrates. The well-defined chiral amplification in the diimines formed results in intense Cotton effects at high wavelengths that can be used for in situ CD analysis of the absolute configuration and ee of cyclic and acyclic substrates.
摘要
缩合两个氨基醇底物后，立体动态、轴向手性三芳基探针被锁定在单一构象中。形成的二亚胺中明确的手性放大导致在高波长处产生强烈的Cotton 效应，可用于环状和非环状底物的绝对构型和 ee 的原位 CD 分析。
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