Department of Geriatric Medicine, University of Erlangen-Nuremberg, Prof. Ernst-Nathan-Strasse 1, 90419 Nuremberg, Germany.
J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):307-11. doi: 10.1093/gerona/glp174. Epub 2009 Nov 11.
The role of the orexigenic hormone ghrelin is of major interest in the altered appetite regulation of the elderly.
Basal and postprandial levels of active and total ghrelin were measured in 15 younger (mean age 35.4 years) and 19 older (80.7 years) participants following a carbohydrate-rich test meal.
Our results showed that older participants felt postprandially less hungry and more full. Although basal levels were not significantly different, active and total ghrelin levels declined postprandially only in the younger study participants. Highly significant differences between the two age groups were shown for the changes of the area under the curve for active ghrelin (p = .024).
Our study demonstrates for the first time that differences in hunger and satiety sensations in relation to age are paralleled by a substantially different response of acylated and total ghrelin, that is, the absence of a postprandial decline in ghrelin levels.
食欲刺激激素胃饥饿素在老年人食欲调节改变中的作用引起了广泛关注。
15 名年轻（平均年龄 35.4 岁）和 19 名年长（80.7 岁）参与者在食用富含碳水化合物的测试餐后，测量基础和餐后活性及总胃饥饿素水平。
我们的结果表明，年长参与者餐后饥饿感降低，饱腹感增强。尽管基础水平没有显著差异，但只有年轻组的参与者餐后活性和总胃饥饿素水平下降。活性胃饥饿素曲线下面积的变化在两个年龄组之间存在高度显著差异（p=0.024）。
本研究首次证明，与年龄相关的饥饿感和饱腹感差异与酰化和总胃饥饿素的反应明显不同，即餐后胃饥饿素水平没有下降。
