2 型糖尿病患者血浆胎球蛋白-A 水平降低与外周动脉疾病的相关性。
Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes.
机构信息
Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Diabetes Care. 2010 Feb;33(2):408-10. doi: 10.2337/dc09-1541. Epub 2009 Nov 12.
OBJECTIVE
Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD).
RESEARCH DESIGN AND METHODS
A total of 738 individuals with type 2 diabetes (mean age 58.7 years, 37.1% female) without known cardiovascular or kidney disease were included in this cross-sectional analysis.
RESULTS
Subjects with PAD had a significantly lower fetuin-A (264.3 vs. 293.4 ng/dl, P < 0.001). In multivariable analysis, a 1-SD decrease in fetuin-A increased the odds of PAD (odds ratio 1.6, P = 0.02). Subgroup analysis revealed an increased odds even in subjects with glomerular filtration rate >80 (odds ratio 1.9, P = 0.05) or high-sensitivity C-reactive protein <3 mg/dl (odds ratio 2.7, P = 0.002).
CONCLUSIONS
Lower circulating fetuin-A is associated with PAD in type 2 diabetes beyond traditional and novel cardiovascular risk factors. Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes.
目的
胎球蛋白 A 是血管钙化的抑制剂和胰岛素抵抗的介质。本研究评估了血浆胎球蛋白 A 与外周动脉疾病（PAD）的关系。
研究设计和方法
本横断面分析共纳入 738 名无已知心血管或肾脏疾病的 2 型糖尿病患者（平均年龄 58.7 岁，37.1%为女性）。
结果
PAD 患者的胎球蛋白 A 水平明显较低（264.3 与 293.4ng/dl，P<0.001）。多变量分析显示，胎球蛋白 A 降低 1 个标准差会增加 PAD 的几率（比值比 1.6，P=0.02）。亚组分析显示，即使在肾小球滤过率>80（比值比 1.9，P=0.05）或高敏 C 反应蛋白<3mg/dl（比值比 2.7，P=0.002）的患者中，这种几率也会增加。
结论
循环胎球蛋白 A 水平降低与 2 型糖尿病患者的 PAD 有关，超出了传统和新型心血管危险因素的范围。我们的发现表明，胎球蛋白 A 缺乏可能作为 2 型糖尿病患者 PAD 的生物标志物具有独特的作用。
Zotero 插件