推进 EPA 指南赞助资助的局部驱虫剂功效研究的科学发展。

Advancing the science of EPA guidelines for sponsor-financed topical insect repellent efficacy studies.

机构信息

University of Florida, 404 McCarty C, P.O. Box 110339, Gainesville, FL 32611-0339, USA.

出版信息

Regul Toxicol Pharmacol. 2010 Feb;56(1):51-3. doi: 10.1016/j.yrtph.2009.11.002. Epub 2009 Nov 13.

DOI:10.1016/j.yrtph.2009.11.002

PMID:19914325

Abstract

In 1999, the US Environmental Protection Agency (EPA) published guidelines for product performance testing of skin-applied insect repellents, which provide guidance for topical insect repellent efficacy studies. EPA subsequently uses these sponsor-financed studies in their evaluation of proposed label claims. This paper reviews some of the statistical flaws in the proposed revisions to these guidelines and suggests possible improvements. This review is important because EPA's revisions to the 1999 guidelines do not address these issues.

摘要

1999 年，美国环境保护署（EPA）发布了皮肤用驱虫剂产品性能测试指南，为驱虫剂功效研究提供了指导。EPA 随后在评估拟议标签声明时使用了这些由赞助商资助的研究。本文回顾了这些指南修订提案中存在的一些统计缺陷，并提出了可能的改进方法。这一审查很重要，因为 EPA 对 1999 年指南的修订并未解决这些问题。