桥连硫代酰胺的合成和重排。

Synthesis and rearrangement of a bridged thioamide.

机构信息

Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Malott Hall, Room 4070, Lawrence, Kaas 66045-7852, USA.

出版信息

Chem Commun (Camb). 2009 Dec 14(46):7122-4. doi: 10.1039/b917508c. Epub 2009 Oct 30.

DOI:10.1039/b917508c

PMID:19921003

Abstract

The synthesis of a bridged thiolactam is described. This thiolactam is shown to undergo an unusual C-N bond cleavage reaction under conditions of its synthesis. Spectroscopic properties of the thiolactam indicate a considerable degree of twist of the thioamide bond.

摘要

描述了一种桥连硫内酰胺的合成。该硫内酰胺在其合成条件下会发生不寻常的 C-N 键断裂反应。硫内酰胺的光谱性质表明硫酰胺键的扭曲程度相当大。