Department of Academic Radiology, University of Otago Christchurch, Christchurch Hospital, Private Bag 4710, Christchurch, 8140, New Zealand.
Pediatr Nephrol. 2010 Mar;25(3):477-83. doi: 10.1007/s00467-009-1348-x.
Infants with mild postnatal renal dilatation but without vesicoureteral reflux pose a challenge. For how long and in what way should they be followed? From May 1989 to December 2006, we prospectively followed 1,795 pregnancies in which the foetal renal pelvis measured 4 mm or greater. Voiding cystourethrography (VCUG) and renal ultrasound were performed on 1,315 infants at 6 weeks of age. Our study group comprised 208 (167 male) infants with normal VCUG findings who had a renal pelvis of 6-11 mm. We followed them for 1-17 years (mean 11 years). Medical and radiological records were reviewed to determine any urinary symptoms and final outcome. They underwent, on average, four further imaging tests. The renal dilatation had resolved by 24 months in approximately 70%. Urinary tract infection (UTI) developed in 16 (8%). Calyceal dilatation was more likely in those developing UTI (P=0.02). Twenty-two (10.6%) had a radiologically demonstrated urinary tract abnormality. Of the five who had renal scarring or severe obstruction, four became symptomatic. Most infants with mild postnatal renal dilatation can be investigated with only one further sonogram at 24 months of age. Mild postnatal renal dilatation is associated with subsequent UTI or renal tract abnormality in 18%. Severe renal abnormality occurred in 2.4%.
对于那些出生后肾脏轻度扩张但无膀胱输尿管反流的婴儿,我们该如何对其进行监测?随访时间及随访方式应该是怎样的?从 1989 年 5 月至 2006 年 12 月,我们前瞻性地随访了 1795 例肾盂宽度≥4mm 的胎儿。在出生后 6 周时,对 1315 例婴儿进行了排尿性膀胱尿道造影(VCUG)和肾脏超声检查。我们的研究组包括 208 例(男婴 167 例)正常 VCUG 结果且肾盂宽度为 6-11mm 的婴儿。对其进行了 1-17 年(平均 11 年)的随访。我们通过查阅医疗和放射学记录,确定其是否存在任何泌尿系统症状和最终结果。这些婴儿平均接受了 4 次进一步的影像学检查。大约 70%的婴儿在 24 个月时肾脏扩张消失。16 例(8%)婴儿发生了尿路感染(UTI)。发生 UTI 的婴儿更易出现肾盏扩张(P=0.02)。22 例(10.6%)存在放射学异常的泌尿道异常。在 5 例有肾瘢痕或严重梗阻的婴儿中,有 4 例出现了症状。大多数轻度产后肾脏扩张的婴儿可以在 24 个月时仅进行一次额外的超声检查。18%的轻度产后肾脏扩张婴儿会出现随后的 UTI 或泌尿道异常,2.4%的婴儿会出现严重的肾脏异常。