胆碱能信号激活的肾素-血管紧张素系统与绵羊胎儿心血管变化有关。
Cholinergic signal activated renin angiotensin system associated with cardiovascular changes in the ovine fetus.
机构信息
Perinatal Origin Diseases Research Institute, First Affiliated Hospital of Soochow University, Suzhou, China.
出版信息
J Perinat Med. 2010;38(1):71-6. doi: 10.1515/jpm.2010.009.
AIM
Cholinergic regulation is important in the control of cardiovascular and endocrine responses. The mechanisms behind cardiovascular responses induced by cholinergic activation are explored by studying hormonal systems, including renin-angiotensin and vasopressin (VP).
RESULTS
In chronically prepared fetal sheep, intravenous infusion of the cholinergic agonist carbachol increased fetal systolic, diastolic, and mean arterial pressure accompanied with bradycardia at near-term. Although intravenous administration of carbachol had no effect on plasma VP concentrations, this agonist increased angiotensin I and angiotensin II levels in fetal plasma. Fetal blood values, including sodium, osmolality, nitric oxide, hemoglobin, and hematocrit were unchanged by intravenous carbachol.
CONCLUSION
Cholinergic activation by carbachol controls fetal blood pressure and heart rate in utero. An over-activated fetal renin-angiotensin-system (RAS) is associated with changes in vascular pressure following intravenous administration of carbachol, indicating that the cholinergic stimulation-mediated hormonal mechanism in the fetus might play a critical role in the regulation of cardiovascular homeostasis.
目的
胆碱能调节在心血管和内分泌反应的控制中很重要。通过研究包括肾素-血管紧张素和血管升压素（VP）在内的激素系统，探索由胆碱能激活引起的心血管反应的机制。
结果
在慢性准备的胎儿羊中，静脉内输注胆碱能激动剂卡巴胆碱可增加胎儿的收缩压、舒张压和平均动脉压，同时伴有接近足月时的心动过缓。尽管静脉内给予卡巴胆碱对血浆 VP 浓度没有影响，但该激动剂增加了胎儿血浆中的血管紧张素 I 和血管紧张素 II 水平。静脉内卡巴胆碱对胎儿血液值，包括钠、渗透压、一氧化氮、血红蛋白和血细胞比容没有影响。
结论
卡巴胆碱的胆碱能激活在子宫内控制胎儿的血压和心率。在静脉内给予卡巴胆碱后，过度激活的胎儿肾素-血管紧张素系统（RAS）与血管压力的变化相关，表明胎儿中胆碱能刺激介导的激素机制可能在心血管稳态的调节中发挥关键作用。
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