对新斯科舍猎鸭寻回犬低肾上腺皮质功能减退候选基因的检查。

Examination of candidate genes for hypoadrenocorticism in Nova Scotia Duck Tolling Retrievers.

机构信息

Department of Animal Science, University of California, Davis, CA 95616, USA.

出版信息

Vet J. 2011 Feb;187(2):212-6. doi: 10.1016/j.tvjl.2009.10.012.

DOI:10.1016/j.tvjl.2009.10.012

PMID:19931476

Abstract

Inherited hypoadrenocorticism occurs in some dog breeds including the Nova Scotia Duck Tolling Retriever (NSDTR) and is thought to be due to an immune attack on the adrenal glands. The genetic cause of this disorder in dogs has not been identified; however, many genes have been associated with hypoadrenocorticism and other immune-mediated conditions in humans including AIRE, BAFF, Casp10, CD28, CTLA-4, FASL, PTPN22, and TNFRSF6B. Microsatellite marker loci were analysed for linkage with the disease phenotype in a pedigree of NSDTRs and excluded all genes examined, the exception being CTLA-4, which was neither excluded nor shown to be associated by this analysis. Thus, genes associated with hypoadrenocorticism in humans were not linked with the condition in the dog. Further examination is necessary to identify the genetic cause of inherited hypoadrenocorticism in dogs and this may reveal a novel gene not yet implicated with immune-mediated disease.

摘要

遗传性肾上腺皮质功能减退症发生在一些犬种中，包括新斯科舍诱鸭寻回猎犬（NSDTR），据认为是由于对肾上腺的免疫攻击。这种犬的遗传原因尚未确定；然而，许多基因与人类的肾上腺皮质功能减退症和其他免疫介导的疾病有关，包括 AIRE、BAFF、Casp10、CD28、CTLA-4、FASL、PTPN22 和 TNFRSF6B。在一个 NSDTR 家系中，对微卫星标记位点进行了与疾病表型的连锁分析，排除了所有检查的基因，唯一的例外是 CTLA-4，该基因既未被排除，也未通过该分析显示与该疾病相关。因此，与人类肾上腺皮质功能减退症相关的基因与犬的这种疾病无关。需要进一步检查以确定犬遗传性肾上腺皮质功能减退症的遗传原因，这可能会揭示一个尚未与免疫介导性疾病相关的新基因。