比较 FT4 与 Abbott Architect ci8200 上的 log TSH：游离甲状腺素和促甲状腺激素的儿科参考区间。
Comparison of FT4 with log TSH on the Abbott Architect ci8200: Pediatric reference intervals for free thyroxine and thyroid-stimulating hormone.
机构信息
General Clinical Research Center, Georgetown University Medical Center, Washington, District of Columbia, USA.
出版信息
Clin Chim Acta. 2010 Feb;411(3-4):250-2. doi: 10.1016/j.cca.2009.11.016. Epub 2009 Nov 24.
BACKGROUND
We evaluated the clinical validity of serum FT4 measurements by assessing its correlation with log TSH. To provide pediatric reference intervals (representative ranges) for FT4, and TSH on the Architect ci8200 integrated system.
METHODS
This population-based study encompassed 6023 children (3369 females and 2654 males). The percentile and Hoffmann approaches for obtaining reference intervals on these analytes were also compared.
RESULTS
FT4 correlation with log TSH was poor ( r=0.010 for males and 0.050 for females). Reference intervals were established. TSH and FT4 did not show a significant sex difference; moreover, the intervals decreased with age for FT4 and TSH.
CONCLUSIONS
Whereas in a previous study ultrafiltration tandem mass spectrometry yielded a correlation of r=0.90 for FT4 vs. log TSH this present study reveals a poor FT4 vs. log TSH correlation in the pediatric population studied and indicates the FT4 immunoassay conducted on the Abbott Architect ci8200 is less useful clinically than might have been expected. Reference intervals using the Hoffmann approach for pediatric in- and out-patients compare well with previously published results utilizing the percentile approach.
背景
我们通过评估 FT4 与 logTSH 的相关性来评估血清 FT4 测量的临床有效性。为了在 Architect ci8200 集成系统上提供适用于儿科的 FT4 和 TSH 的参考区间（代表性范围）。
方法
本基于人群的研究包括 6023 名儿童（3369 名女性和 2654 名男性）。还比较了百分位数和 Hoffmann 方法获得这些分析物参考区间的效果。
结果
FT4 与 logTSH 的相关性较差（男性 r=0.010，女性 r=0.050）。建立了参考区间。TSH 和 FT4 没有表现出显著的性别差异；此外，FT4 和 TSH 的间隔随着年龄的增长而减小。
结论
虽然在之前的研究中，超滤串联质谱法得出的 FT4 与 logTSH 的相关性 r=0.90，但本研究表明，在所研究的儿科人群中，FT4 与 logTSH 的相关性较差，这表明 Abbott Architect ci8200 上进行的 FT4 免疫测定在临床上的实用性不如预期。使用 Hoffmann 方法为儿科门诊和住院患者建立的参考区间与之前使用百分位数方法发表的结果相比非常吻合。
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