Rigal E, Maakaroun-Vermesse Z, Gaudy-Graffin C, Bonnemaison E, Marchand S, Labarthe F, Maurage C
Service pédiatrie R, pôle de pédiatrie, hôpital Clocheville, CHU de Tours, 49, boulevard Béranger, 37044 Tours cedex 1, France.
Arch Pediatr. 2010 Jan;17(1):26-33. doi: 10.1016/j.arcped.2009.10.008. Epub 2009 Nov 20.
Human metapneumovirus (hMPV), a recently identified respiratory virus, is a leading cause of acute respiratory tract infection in children during winter. The aims of this study were to outline epidemiological and clinical presentations of hMPV infectious diseases in young children.
A prospective study was conducted from November 2007 to April2008 in children under 2 years of age admitted to the University Children's Hospital of Tours, France, for acute respiratory infection. Nasopharyngeal aspirates were systematically tested for several respiratory viruses. Epidemiological and clinical characteristics of hMPV-infected children were compared to those of patients with respiratory syncytial virus (RSV) and other viral (OTH) infections.
A total of 374 children were enrolled in this study. Viral investigations detected 22 (6 %) hMPV infections, 177 (47 %) RSV infections, and 175 (47 %) presumed or demonstrated other viruses. The hMPV infection had a seasonal peak in December, similar to RSV, and was uncommon after January. Most of the patients infected with hMPV were under 1 year of age and bronchiolitis was the predominant diagnosis in 90 % of these patients with clinical symptoms of a lower respiratory tract infection. The severity of the disease, estimated from the requirement of respiratory or nutritional assistance, was similar to those of RSV patients, but was higher than those in the OTH group. hMPV was more frequently detected in patients with chronic pathology, such as bronchopulmonary dysplasia, congenital heart defect, or neuromuscular disorders, and in patients who had been previously admitted for bronchiolitis.
These results highlight that hMPV plays an important role in seasonal acute respiratory tract infections in children during winter, with a severity similar to RSV infections.
人偏肺病毒（hMPV）是一种最近发现的呼吸道病毒，是冬季儿童急性呼吸道感染的主要病因。本研究的目的是概述幼儿hMPV感染性疾病的流行病学和临床表现。
2007年11月至2008年4月，对法国图尔大学儿童医院收治的2岁以下急性呼吸道感染儿童进行了一项前瞻性研究。对鼻咽抽吸物系统检测多种呼吸道病毒。将hMPV感染儿童的流行病学和临床特征与呼吸道合胞病毒（RSV）感染及其他病毒（OTH）感染患者的特征进行比较。
本研究共纳入374名儿童。病毒检测发现22例（6%）hMPV感染、177例（47%）RSV感染以及175例（47%）疑似或确诊的其他病毒感染。hMPV感染在12月出现季节性高峰，与RSV相似，1月后则不常见。大多数感染hMPV的患者年龄在1岁以下，90%有下呼吸道感染临床症状的此类患者主要诊断为细支气管炎。根据呼吸或营养支持需求评估的疾病严重程度与RSV感染患者相似，但高于OTH组。hMPV在患有慢性疾病（如支气管肺发育不良、先天性心脏病或神经肌肉疾病）的患者以及先前因细支气管炎入院的患者中更频繁被检测到。
这些结果表明，hMPV在冬季儿童季节性急性呼吸道感染中起重要作用，严重程度与RSV感染相似。
