钌（II）多吡啶配合物的合成、DNA 结合、光解、细胞毒性和抗氧化活性。
Synthesis, DNA-binding, photocleavage, cytotoxicity and antioxidant activity of ruthenium (II) polypyridyl complexes.
机构信息
School of Pharmacy, Guangdong Pharmaceutical University, Guangdong, Guangzhou 510006, PR China.
出版信息
Eur J Med Chem. 2010 Feb;45(2):564-71. doi: 10.1016/j.ejmech.2009.10.043. Epub 2009 Nov 4.
Two new ligands maip (1a), paip (1b) with their ruthenium (II) complexes Ru(bpy)(2)(maip)(2) (2a) and Ru(bpy)(2)(paip)(2) (2b) have been synthesized and characterized. The results show that complexes 2a and 2b interact with DNA through intercalative mode. The cytotoxicity of these compounds has been evaluated by MTT assay. The experiments on antioxidant activity show that these compounds exhibit good antioxidant activity against hydroxyl radical (OH).
两种新的配体 maip（1a）和 paip（1b）及其钌（II）配合物 Ru(bpy)(2)(maip)(2)（2a）和 Ru(bpy)(2)(paip)(2)（2b）已被合成并进行了表征。结果表明，配合物 2a 和 2b 通过嵌入模式与 DNA 相互作用。通过 MTT 测定法评估了这些化合物的细胞毒性。抗氧化活性实验表明，这些化合物对羟基自由基（OH）表现出良好的抗氧化活性。
Zotero 插件