Visvader Jane E
VBCRC (Victorian Breast Cancer Research Consortium) Laboratory, The Walter and Eliza Hall of Medical Research, Parkville, Victoria 3052, Australia.
Genes Dev. 2009 Nov 15;23(22):2563-77. doi: 10.1101/gad.1849509.
The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent identification of stem and progenitor populations in mouse and human mammary tissue has provided evidence that the mammary epithelium is organized in a hierarchical manner. Characterization of these normal epithelial subtypes is an important step toward understanding which cells are predisposed to oncogenesis. This review summarizes progress in the field toward defining constituent cells and key molecular regulators of the mammary epithelial hierarchy. Potential relationships between normal epithelial populations and breast tumor subtypes are discussed, with implications for understanding the cellular etiology underpinning breast tumor heterogeneity.
乳腺上皮处于高度动态的状态，在青春期、怀孕期、哺乳期和退化期经历显著的形态发生变化。最近在小鼠和人类乳腺组织中鉴定出干细胞和祖细胞群体，这为乳腺上皮以分层方式组织提供了证据。对这些正常上皮亚型的表征是理解哪些细胞易发生肿瘤形成的重要一步。本综述总结了该领域在定义乳腺上皮层次结构的组成细胞和关键分子调节因子方面的进展。讨论了正常上皮群体与乳腺肿瘤亚型之间的潜在关系，这对于理解支撑乳腺肿瘤异质性的细胞病因学具有重要意义。
