Stulberg B N, Watson J T, Stulberg S D, Bauer T W, Manley M T
Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Ohio.
Clin Orthop Relat Res. 1991 Feb(263):288-302.
A model to assess tibial fixation in knee arthroplasty is described. Eighteen mongrel dogs were implanted with a right tibial hemiarthroplasty. Implantation was of a press-fit, smooth implant (eight dogs) or a titanium alloy beaded device (ten dogs). Animals were studied at six, 12, 18, and 24 weeks. Roentgenographic and histologic analysis was performed for all implants. All animals were ambulatory. Roentgenographically, smooth implants showed progressive radiolucencies with increasing trabecular sclerosis under the implants. These changes were less prominent under the porous implants. Histologically, fibrous interfaces were identified focally under all implants but were thicker under smooth devices. Eighteen- and 24-week specimens showed substantial ingrowth into the porous pegs but minimal ingrowth into the porous plateau. Concurrent histologic and biochemical evaluation in dogs demonstrates the possible fate of implants in knee arthroplasty in human beings. As has been observed, histologic analyses suggest that clinically satisfactory results do not constitute evidence of stabilization by bone ingrowth.
描述了一种用于评估膝关节置换术中胫骨固定的模型。18只杂种狗接受了右胫骨半关节置换术。植入的是压配式光滑植入物（8只狗）或钛合金带珠装置（10只狗）。在6周、12周、18周和24周对动物进行研究。对所有植入物进行了X线和组织学分析。所有动物均可行走。在X线片上，光滑植入物下方显示出逐渐增加的放射性透亮区，伴有小梁硬化增加。这些变化在多孔植入物下方不太明显。在组织学上，在所有植入物下方均局灶性地发现了纤维界面，但在光滑装置下方更厚。18周和24周的标本显示大量长入多孔钉，但长入多孔平台的很少。对狗进行的同步组织学和生化评估证明了人类膝关节置换术中植入物的可能转归。如所观察到的，组织学分析表明临床满意的结果并不构成骨长入稳定的证据。
