评估一项针对产前酒精暴露儿童的早期干预项目的神经认知效果。
Estimating the neurocognitive effects of an early intervention program for children with prenatal alcohol exposure.
作者信息
Yazdani Parvaneh, Motz Mary, Koren Gideon
机构信息
ivision of Clinical Pharmacology &Toxicology, Hospital for Sick Children andUniversity of Toronto, Toronto.
出版信息
Can J Clin Pharmacol. 2009 Fall;16(3):e453-9. Epub 2009 Nov 19.
BACKGROUND
Animal studies suggest that early intervention in pups exposed heavily to ethanol in utero can mitigate their neurocognitive damage. No human studies on this promising mechanism exists.
METHODS
Breaking the Cycle is an early intervention program for drug-and alcohol addicted mothers and their young children. We compared BSID-III scores between infants heavily exposed to ethanol and a group exposed only to drugs of abuse, mainly cocaine. Both groups benefited from all aspects of our early intervention program.
RESULTS
The two groups did not differ in any aspect of the BSID-III. These data are in contradistinction to the damage seen in heavily ethanol- exposed infants not benefiting from early intervention.
CONCLUSIONS
This pilot suggests that early intervention may mitigate some of the well described damages caused by heavy in utero alcohol exposure.
背景
动物研究表明，对子宫内大量接触乙醇的幼崽进行早期干预可减轻其神经认知损伤。目前尚无关于这一有前景机制的人体研究。
方法
“打破循环”是一项针对吸毒和酗酒成瘾母亲及其幼儿的早期干预项目。我们比较了大量接触乙醇的婴儿与仅接触滥用药物（主要是可卡因）的一组婴儿的贝利婴幼儿发展量表第三版（BSID-III）得分。两组均从我们早期干预项目的各个方面中受益。
结果
两组在BSID-III的任何方面均无差异。这些数据与未受益于早期干预的大量接触乙醇婴儿所出现的损伤形成对比。
结论
这项试点研究表明，早期干预可能减轻子宫内大量酒精暴露所造成的一些已被充分描述的损伤。
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