氯吡格雷和阿司匹林致胃肠道出血。

Gastrointestinal bleed with clopidogrel and aspirin.

机构信息

Pediatric Cardiology and Congenital Cardiac Centre, Indraprastha Apollo Hospital, New Delhi, India.

出版信息

Indian J Pediatr. 2010 Jan;77(1):101-2. doi: 10.1007/s12098-009-0264-1.

DOI:10.1007/s12098-009-0264-1

PMID:19936651

Abstract

Anti-platelet drugs have been used to prevent thrombosis of systemic to pulmonary artery shunts. Aspirin has traditionally been used. Clopidogrel is being studied as an alternative and in combination with aspirin for shunt patients. We report a near fatal gastro-intestinal bleed in a patient with shunt and on aspirin and clopidogrel. This combination has been known to produce similar bleeds. The authors recommend caution in combining them. Prospective studies currently underway should evaluate this aspect of the antiplatelet drugs.

摘要

抗血小板药物已被用于预防体肺分流术的血栓形成。传统上使用阿司匹林。氯吡格雷正在被研究作为一种替代药物，并与阿司匹林联合用于分流患者。我们报告了一例使用阿司匹林和氯吡格雷的分流患者发生致命性胃肠出血的病例。这种组合已知会导致类似的出血。作者建议在联合使用时要谨慎。目前正在进行的前瞻性研究应该评估抗血小板药物的这一方面。