AKT 激酶在麻疹病毒复制中的作用。
Role of AKT kinase in measles virus replication.
机构信息
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA.
出版信息
J Virol. 2010 Feb;84(4):2180-3. doi: 10.1128/JVI.01316-09. Epub 2009 Nov 25.
Abstract
Many RNA and DNA viruses activate serine-threonine kinase AKT to increase virus replication. In contrast, measles virus (MV) infection leads to downregulation of AKT. This is thought to be beneficial for the virus because it correlates with immune suppression. To determine whether this is a sacrifice for the virus, we used a recombinant virus and transfected cells expressing constitutively active AKT and evaluated its effect on virus replication. In vitro, overexpression of AKT did not influence virus replication but did affect (cell-type dependent) virus release. In vivo, the recombinant virus did not abrogate inhibition of proliferation of spleen cells from MV-infected cotton rats.
摘要
许多 RNA 和 DNA 病毒激活丝氨酸-苏氨酸激酶 AKT 以增加病毒复制。相比之下，麻疹病毒 (MV) 感染会导致 AKT 下调。这被认为对病毒有益，因为它与免疫抑制有关。为了确定这是否是病毒的牺牲，我们使用重组病毒和转染表达组成性激活 AKT 的细胞，并评估其对病毒复制的影响。在体外，AKT 的过表达不会影响病毒复制，但会影响（细胞类型依赖性）病毒释放。在体内，重组病毒不会消除 MV 感染棉鼠脾细胞增殖抑制的作用。
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2
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Recent Pat Biotechnol. 2008;2(3):218-26. doi: 10.2174/187220808786241042.
3
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4
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Vaccine. 2007 Dec 17;25(52):8782-93. doi: 10.1016/j.vaccine.2007.10.038. Epub 2007 Nov 5.
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