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Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.
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Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas.
Br J Cancer. 2009 Feb 24;100(4):626-32. doi: 10.1038/sj.bjc.6604896.
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Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage.
Exp Cell Res. 2008 May 1;314(8):1860-8. doi: 10.1016/j.yexcr.2008.02.008. Epub 2008 Feb 29.
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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
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Apoptosis and autophagy after mitochondrial or endoplasmic reticulum photodamage.
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The death of human cancer cells following photodynamic therapy: apoptosis competence is necessary for Bcl-2 protection but not for induction of autophagy.
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Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy.
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