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EORTC 老年肿瘤专家组关于老年结肠癌患者治疗的观点。

EORTC Elderly Task Force experts' opinion for the treatment of colon cancer in older patients.

机构信息

EORTC Headquarters, EORTC-Elderly Task Force, Brussels, Belgium.

出版信息

Cancer Treat Rev. 2010 Feb;36(1):83-90. doi: 10.1016/j.ctrv.2009.10.008. Epub 2009 Nov 26.

Abstract

As a result of an increasing life expectancy, the incidence of colon cancer in the older population is rising. As a consequence oncologists and their older patients commonly face the dilemma of whether or not to give/receive treatment for colon cancer. However, the paucity of large, well conducted prospective trials makes it difficult to provide evidence-based clinical recommendations for these patients. The current evidence supports the safety and efficacy of treatment for colon cancer in fit older patients and demonstrates that treatment outcome can be similar to that of their younger counterparts. However, it should be noted that these data are derived from retrospective studies which are likely to suffer from selection bias. Despite a growing body of data, further work is still needed to establish optimal strategies to care for this special population and prospective specific trials for older colon cancer patients are clearly needed.

摘要

由于预期寿命的延长,老年人群中结肠癌的发病率正在上升。因此,肿瘤学家及其老年患者通常面临着是否给予/接受结肠癌治疗的困境。然而,由于缺乏大型、精心设计的前瞻性试验,很难为这些患者提供基于证据的临床建议。目前的证据支持在健康的老年患者中治疗结肠癌的安全性和有效性,并表明治疗结果可以与年轻患者相似。然而,应该注意的是,这些数据来自于可能存在选择偏倚的回顾性研究。尽管有越来越多的数据,但仍需要进一步的工作来确定为这一特殊人群提供最佳护理的策略,并且显然需要针对老年结肠癌患者的前瞻性特定试验。

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