Benfey B G
Fed Proc. 1977 Nov;36(12):2575-9.
Isolated heart preparations of frog and rat were used to test the validity of the adrenoceptor interconversion hypothesis. This hypothesis claims that low temperature converts the inotropic beta-adrenoceptors in isolated frog and rat heart to alpha-adrenoceptors. The present results do not support the adrenoceptor interconversion hypothesis. In the isolated frog ventricle, lowering the temperature from 24 C to 14 C did not significantly alter the inotropic potency of the sympathomimetic drugs isoprenaline, epinephrine, and phenylephrine and did not reduce the potency of the beta-adrenoceptor blocking drug propranolol as an epinephrine antagonist. In the isolated rat left atrium, lowering the temperature from 31 C to 17-19 C did not significantly change the inotropic potency of isoprenaline, norepinephrine and phenylephrine, did not diminish the potency of propranolol, and did not increase the potency of the alpha-adrenoceptor blocking drug phentolamine.--Benfey, B. G. Cardiac adrenoceptors at low temperature; what is the experimental evidence for the adrenoceptor interconversion hypothesis?
使用青蛙和大鼠的离体心脏制剂来检验肾上腺素能受体相互转化假说的有效性。该假说声称低温可将离体青蛙和大鼠心脏中的变力性β-肾上腺素能受体转化为α-肾上腺素能受体。目前的结果不支持肾上腺素能受体相互转化假说。在离体青蛙心室中，将温度从24℃降至14℃并不会显著改变拟交感神经药物异丙肾上腺素、肾上腺素和去氧肾上腺素的变力效力，也不会降低β-肾上腺素能阻断药物普萘洛尔作为肾上腺素拮抗剂的效力。在离体大鼠左心房中，将温度从31℃降至17 - 19℃并不会显著改变异丙肾上腺素、去甲肾上腺素和去氧肾上腺素的变力效力，不会降低普萘洛尔的效力，也不会增加α-肾上腺素能阻断药物酚妥拉明的效力。——本菲，B.G. 低温下的心脏肾上腺素能受体；肾上腺素能受体相互转化假说的实验证据是什么？
