Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA.
Int J Geriatr Psychiatry. 2010 Aug;25(8):780-8. doi: 10.1002/gps.2418.
To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH).
Thirty-seven patients with probable AD received the Neuropsychiatric Inventory (NPI), the Mini Mental Status Exam (MMSE), and an MRI scan as part of their initial evaluation at the Outpatient Memory Diagnostic Clinic at McLean Hospital. MRI-based volumetric measurements of whole brain atrophy, hippocampal volumes, and WMH were obtained. Analysis of covariance models, using age as a covariate and the presence of specific BPSD as independent variables, were used to test for differences in whole brain volumes, hippocampal volumes and WMH volumes.
Increased WMH were associated with symptoms of anxiety, aberrant motor behavior, and night time disturbance, while symptoms of disinhibition were linked to lower WMH volume. No associations were found for whole brain or hippocampal volumes and BPSD.
These findings suggest that white matter changes are associated with the presence of BPSD in AD.
研究阿尔茨海默病(AD)患者的行为和心理症状(BPSD)与脑萎缩和脑白质高信号(WMH)的磁共振成像(MRI)测量值之间的关系。
37 名可能患有 AD 的患者接受了神经精神问卷(NPI)、简易精神状态检查(MMSE)和 MRI 扫描,作为他们在麦克莱恩医院门诊记忆诊断诊所初始评估的一部分。获得了基于 MRI 的全脑萎缩、海马体积和 WMH 的容积测量值。使用协方差分析模型,以年龄为协变量,特定 BPSD 为自变量,测试全脑容积、海马体积和 WMH 容积的差异。
WMH 增加与焦虑、异常运动行为和夜间障碍有关,而脱抑制症状与较低的 WMH 体积有关。未发现 BPSD 与全脑或海马体积之间存在关联。
这些发现表明,在 AD 中,白质变化与 BPSD 的存在有关。