Hamaoui Abraham, Mercado Ray
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, Bronx, New York, USA.
J Reprod Med. 2009 Sep;54(9):587-90.
Myasthenia gravis in pregnancy is uncommon, and its occurrence in conjunction with preeclampsia is very rare but may be catastrophic for mother and child.
A 31-year-old, multiparous woman, with a history of myasthenia gravis and thymectomy, presented at 27 weeks with worsening preeclampsia and delivered by cesarean section under spinal anesthesia. Preeclamptic crisis with hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome developed postpartum. Blood pressures remained severely high. Intensive care management and a labetalol drip resolved the crisis.
Added complications may arise from myasthenic exacerbation, difficulties in early recognition of signs and symptoms, and the use of medications that slow neuromuscular transmission.
妊娠合并重症肌无力并不常见,而同时合并子痫前期则极为罕见,但这对母婴可能是灾难性的。
一名31岁经产妇,有重症肌无力病史且已行胸腺切除术,孕27周时出现子痫前期病情加重,在脊髓麻醉下行剖宫产分娩。产后发生了伴有溶血、肝酶升高和血小板减少(HELLP)综合征的子痫前期危象。血压持续严重升高。重症监护管理及静脉滴注拉贝洛尔解决了危象。
重症肌无力病情加重、早期难以识别症状体征以及使用减慢神经肌肉传递的药物可能会引发更多并发症。