5-羟色胺能系统：其在自闭症发病机制和早期发育治疗中的作用。
The serotonergic system: its role in pathogenesis and early developmental treatment of autism.
机构信息
1st Department of Pediatrics, Aristotle University of Thessaloniki, Greece.
出版信息
Curr Neuropharmacol. 2009 Jun;7(2):150-7. doi: 10.2174/157015909788848848.
Abstract
Autism is a severe childhood disorder already presenting in the first 3 years of life and, therefore, strongly correlated with neurodevelopmental alterations in prenatal, as well as postnatal period. Neurotransmitters hold a pivotal role in development by providing the stimulation needed for synapses and neuronal networks to be formed during the critical period of neuroplasticity. Aberrations of the serotonergic system modify key processes in the developing brain and are strongly implicated in the pathophysiology of developmental disorders. Evidence for the role of serotonin in autism emerges from neuropathological, imaging and genetic studies. Due to its developmental arrest, autism requires early intervention that would, among others, target the disrupted serotonergic system and utilize brain plasticity to elicit clinically important brain changes in children.
摘要
自闭症是一种严重的儿童期疾病，在生命的头 3 年内就已出现，因此与产前和产后的神经发育改变密切相关。神经递质在发育过程中起着关键作用，为突触和神经元网络在神经可塑性的关键时期形成提供所需的刺激。血清素能系统的异常改变了发育中大脑的关键过程，并强烈提示其与发育障碍的病理生理学有关。神经病理学、影像学和遗传学研究都证明了血清素在自闭症中的作用。由于自闭症的发育停滞，需要早期干预，除其他外，干预目标是失调的血清素能系统，并利用大脑的可塑性，使儿童的大脑发生临床上有重要意义的变化。
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