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[一名看似免疫功能正常患者的播散性隐球菌病]

[Disseminated cryptococcosis in an apparently immunocompetent patient].

作者信息

El Ouazzani H, Achachi L, Belkhiri S, El Ftouh M, El Fassy Fihry M-T

机构信息

Service de Pneumologie, CHU Ibn Sina, Rabat, Maroc.

出版信息

Rev Mal Respir. 2009 Sep;26(7):788-93. doi: 10.1016/s0761-8425(09)72432-5.

Abstract

Cryptococcal infections occur frequently in immunocompromised patients particularly in the context of AIDS, lymphomas and following immunosuppression for organ transplant recipients. In these contexts the infection is readily considered and diagnosis straightforward. The diagnosis is rarer and thus less likely to be considered in immunocompetent patients which can lead to late diagnosis and delay in initiation of therapy. We report the case of disseminated cryptococcosis with endobronchial, cutaneous, bone and meningeal involvement in an apparently immunocompetent patient. Before antifungal treatment could be initiated the patient died of cerebral complications.

摘要

隐球菌感染在免疫功能低下的患者中经常发生,特别是在艾滋病、淋巴瘤患者以及器官移植受者免疫抑制之后的情况下。在这些情况下,感染很容易被考虑到,诊断也很直接。在免疫功能正常的患者中,诊断较为罕见,因此不太可能被考虑到,这可能导致诊断延迟和治疗开始延迟。我们报告了一例明显免疫功能正常的患者发生播散性隐球菌病,累及支气管内、皮肤、骨骼和脑膜。在开始抗真菌治疗之前,患者死于脑部并发症。

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