Li Y F, Luo E, Feng G, Zhu S S, Li J H, Hu J
The State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, NO. 14, Section 3, Southern Renmin Road, Chendgu, 610041, China.
Osteoporos Int. 2010 Nov;21(11):1889-97. doi: 10.1007/s00198-009-1140-6. Epub 2009 Dec 3.
Systemic treatment with strontium ranelate (SR) was performed on ovariectomized (OVX) rats with fractured tibiae. Callus quality was assessed by radiographic, histological, micro-computerized tomography, and biomechanical examinations at 4 and 8 weeks after fracture. Results revealed that systemic applied SR promoted osteoporotic fracture healing.
Several studies have demonstrated the dual effect of SR on osteoporotic and undisturbed bone. However, reports of their effect on osteoporotic fracture healing are limited. This study was designed to investigate the effects of SR on bone regeneration in OVX rats with fractured tibiae.
Three months after being OVX, female Sprague-Dawley rats accepted bilateral osteotomy on proximal tibiae fixed with intramedullary wires and were divided into two groups: OVX and OVX + SR (625 mg/kg/day). Callus quality was evaluated at 4 and 8 weeks postfracture.
Compared with OVX group, SR treatment significantly increased bone formation, BMD, biomechanical strength, and improved microstructural properties of the callus. The ultimate load was increased by 211.0% and 61.4% (p<0.01), and the total bone volume of callus by 74.8% and 79.3% (p<0.01) at 4 and 8 weeks postfracture, respectively. SR treatment also promoted healing progress with increased osteogenesis at 4 weeks; more mature and tightly arranged woven or lamellar bone at 8 weeks across the fracture gap in histological analysis.
This study suggests that systemic treatment with strontium ranelate could promote tibial fracture healing in OVX rats.
对胫骨骨折的去卵巢（OVX）大鼠进行雷奈酸锶（SR）全身治疗。在骨折后4周和8周，通过放射学、组织学、微型计算机断层扫描和生物力学检查评估骨痂质量。结果显示，全身应用SR可促进骨质疏松性骨折愈合。
多项研究已证明SR对骨质疏松性骨和正常骨具有双重作用。然而，关于其对骨质疏松性骨折愈合影响的报道有限。本研究旨在探讨SR对OVX胫骨骨折大鼠骨再生的影响。
OVX术后3个月，雌性Sprague-Dawley大鼠接受双侧胫骨近端截骨术，用髓内针固定，并分为两组：OVX组和OVX + SR组（625 mg/kg/天）。在骨折后4周和8周评估骨痂质量。
与OVX组相比，SR治疗显著增加了骨形成、骨密度、生物力学强度，并改善了骨痂的微观结构特性。骨折后4周和8周，极限载荷分别增加了211.0%和61.4%（p<0.01），骨痂的总骨体积分别增加了74.8%和79.3%（p<0.01）。SR治疗还促进了愈合进程，在4周时增加了成骨；在组织学分析中，8周时骨折间隙处有更成熟且排列紧密的编织骨或板层骨。
本研究表明，雷奈酸锶全身治疗可促进OVX大鼠胫骨骨折愈合。
