经皮电刺激穴位与子宫内膜异位症相关慢性盆腔痛的临床相关性的皮肤电测量。
Electrodermal measures of Jing-Well points and their clinical relevance in endometriosis-related chronic pelvic pain.
机构信息
Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, 401 Park Drive Suite 22A-West, Boston, MA 02215, USA.
出版信息
J Altern Complement Med. 2009 Dec;15(12):1293-305. doi: 10.1089/acm.2008.0597.
OBJECTIVES
To determine whether electrodermal measures at Jing-Well acupuncture points, "indicator" points located at the tips of fingers and toes are associated with clinical measures in adolescent women with chronic pelvic pain.
DESIGN
The design of this study was a randomized sham-controlled trial. Analyses of electrodermal measures were based on longitudinal, multivariable analyses using generalized estimating equations.
SUBJECTS AND SETTING
The subjects were 14 young women (ages 14-22) with laparoscopically diagnosed endometriosis and chronic pelvic pain. Subjects were randomized to sham acupuncture or Japanese-style active acupuncture. Sixteen (16) treatments were administered over 8 weeks.
OUTCOME MEASURES
Using a Hibiki-7 device, electrodermal impedance measures were obtained at all 24 Jing-Well points for each treatment visit. From these readings, measures of "imbalance" were determined by calculating statistical dispersion (statistical deviation and Gini coefficient) and level of asymmetry (left-right, top-bottom, and yin-yang). Clinical outcome measures were obtained at baseline, week 4, and week 8 and included level of pelvic pain, Endometriosis Health Profile, Pediatric Quality of Life, perceived stress, and inflammatory cytokine levels (interleukin-6 and tumor necrosis factor-alpha).
RESULTS
Participants designated to the acupuncture group had, on average, a substantial decrease in statistical dispersion and asymmetry of Hibiki-7 values over the course of treatment compared to the sham group. Electrodermal asymmetry variables, specifically either yin-yang or left-right measure, were significantly associated with pelvic pain, Endometriosis Health Profile, Pediatric Quality of Life, and Perceived Stress even after adjusting for treatment designation. No associations between electrodermal balance measures and inflammatory cytokines were found.
CONCLUSIONS
Electrodermal measures may be significantly associated with clinical outcome and acupuncture treatments in adolescent women with chronic pelvic pain.
目的
确定经穴（位于指尖和趾尖的“指示”点）的皮肤电测量值是否与患有慢性盆腔疼痛的青春期女性的临床指标相关。
设计
本研究的设计为随机假对照试验。皮肤电测量的分析基于使用广义估计方程的纵向多变量分析。
研究对象和设置
研究对象为 14 名（年龄 14-22 岁）经腹腔镜诊断为子宫内膜异位症和慢性盆腔疼痛的年轻女性。受试者随机分为假针刺组或日式主动针刺组。在 8 周内进行 16 次治疗。
观察指标
使用 Hibiki-7 设备，在每次治疗就诊时，对所有 24 个经穴进行皮肤电阻抗测量。根据这些读数，通过计算统计离散度（统计偏差和基尼系数）和不对称程度（左右、上下和阴阳）来确定“失衡”的指标。在基线、第 4 周和第 8 周时，通过获取盆腔疼痛水平、子宫内膜异位症健康状况评分、儿科生活质量评分、感知压力和炎症细胞因子水平（白细胞介素-6 和肿瘤坏死因子-α）来评估临床结果。
结果
与假针刺组相比，接受针刺组的参与者在治疗过程中，Hibiki-7 值的统计离散度和不对称性平均有明显下降。皮肤电不对称变量，特别是阴阳或左右测量值，与盆腔疼痛、子宫内膜异位症健康状况评分、儿科生活质量评分和感知压力显著相关，即使在调整治疗分组后也是如此。但未发现皮肤电平衡指标与炎症细胞因子之间存在关联。
结论
皮肤电测量值可能与青春期患有慢性盆腔疼痛的女性的临床结果和针刺治疗显著相关。
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