Hummel M, Fuechtenbusch M
Institut für Diabetesforschung der Forschergruppe Diabetes e. V. am Helmholtz-Zentrum München.
Z Gastroenterol. 2009 Dec;47(12):1216-20. doi: 10.1055/s-0028-1109857. Epub 2009 Dec 3.
According to our knowledge and for the first time we refer about the combination therapy with gastric electric stimulation and injection of botulinus toxin into the pylorus at a patient with increased symptomatic diabetic gastroparesis for the first time. The prospectively documented gastroparesis-symptom-score improved dramatically under this combination therapy, while time of gastric emptying of 50 % (specified by scintigraphy) was showing solely a low decrease. 18 months after beginning the combination therapy its positive effect is to be watched furthermore, complications haven't occurred yet. The combination therapy with gastric electric stimulation and injection of botulinus toxin into the pylorus demonstrates one option of therapy-refractory diabetic gastroparesis, which has to be verified, however, in prospective studies in terms of its effectiveness.
据我们所知,我们首次提及对一名症状性糖尿病胃轻瘫加重患者采用胃电刺激与向幽门注射肉毒杆菌毒素的联合治疗。在这种联合治疗下,前瞻性记录的胃轻瘫症状评分显著改善,而通过闪烁扫描确定的胃排空50%的时间仅略有下降。联合治疗开始18个月后,其积极效果仍有待进一步观察,尚未出现并发症。胃电刺激与向幽门注射肉毒杆菌毒素的联合治疗是治疗难治性糖尿病胃轻瘫的一种选择,然而,其有效性必须在前瞻性研究中得到验证。