Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, Department of Cardiology, Istanbul, Turkey.
Med Hypotheses. 2010 Apr;74(4):665-7. doi: 10.1016/j.mehy.2009.11.010. Epub 2009 Dec 3.
Atrial fibrillation is a frequent arrhythmia, and atherosclerotic coronary artery disease remains as the most common etiological factor underlying atrial fibrillation, along with systemic hypertension. The relationship between uncomplicated coronary artery disease and atrial fibrillation is not explained satisfactorily. Inflammation is now recognized as an important pathogenetic mechanism for both disorders. We hypothesise that inflammation originated from atherosclerotic coronary arteries may disseminate downstream to atrial tissue and initiate or stabilize atrial fibrillation. Studies conducted with drugs bearing anti-inflammatory properties such as hydroxymethylglutaryl coenzyme A inhibitors decrease frequency of both conditions. Such a relationship may become a novel therapeutic target to prevent this arrhythmia or decrease the frequency of paroxysms.
心房颤动是一种常见的心律失常，动脉粥样硬化性冠状动脉疾病仍然是心房颤动的最常见病因，同时还伴有全身性高血压。单纯性冠状动脉疾病与心房颤动之间的关系尚未得到充分解释。炎症目前被认为是这两种疾病的重要发病机制。我们假设源自动脉粥样硬化性冠状动脉的炎症可能向下游传播至心房组织，并引发或稳定心房颤动。具有抗炎特性的药物（如羟甲基戊二酰辅酶 A 抑制剂）的研究降低了这两种疾病的发生频率。这种关系可能成为预防这种心律失常或减少阵发性发作的新的治疗靶点。
