Unité de Bioénergétique et Ingénierie des Protéines, Centre National de la Recherche Scientifique, 31 chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France.
J Theor Biol. 2010 Mar 7;263(1):79-92. doi: 10.1016/j.jtbi.2009.11.010. Epub 2009 Dec 3.
The major insight in Robert Rosen's view of a living organism as an (M,R)-system was the realization that an organism must be "closed to efficient causation", which means that the catalysts needed for its operation must be generated internally. This aspect is not controversial, but there has been confusion and misunderstanding about the logic Rosen used to achieve this closure. In addition, his corollary that an organism is not a mechanism and cannot have simulable models has led to much argument, most of it mathematical in nature and difficult to appreciate. Here we examine some of the mathematical arguments and clarify the conditions for closure.
罗伯特·罗森（Robert Rosen）将生物体视为（M，R）系统的主要观点是，生物体必须“对有效因果关系封闭”，这意味着其运作所需的催化剂必须在内部产生。这一方面没有争议，但对于罗森用于实现这种封闭的逻辑，存在混淆和误解。此外，他的推论是生物体不是机制，也不能有可模拟的模型，这引发了很多争论，其中大部分是数学性质的，难以理解。在这里，我们检查了一些数学论点，并阐明了封闭的条件。
