A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia.
作者信息
Sárová Iveta, Brezinová Jana, Zemanová Zuzana, Lizcová Libuse, Berková Adéla, Izáková Silvia, Malinová Eva, Fuchs Ota, Kostecka Arnost, Provazníková Dana, Filkuková Jitka, Maaloufová Jacqueline, Starý Jan, Michalová Kyra
机构信息
Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic.
出版信息
Cancer Genet Cytogenet. 2009 Dec;195(2):150-6. doi: 10.1016/j.cancergencyto.2009.05.008.
Unusual MLL gene rearrangements were found in bone marrow cells of four patients with acute myeloid leukemia. A combination of conventional and molecular cytogenetic methods were used to describe translocations t(9;12;11)(p22;p13;q23), t(11;19)(q23;p13.3), and t(10;11)(p12;23) and inverted insertion ins(10;11)(p12;q23.3q23.1). Partial nontandem duplication of the MLL gene was identified by reverse transcriptase-polymerase chain reaction in all cases. The duplication, which included MLL exons 2 through 8-9, was interrupted by a cryptic insertion of one or two exons from the respective MLL partner gene: MLLT10, MLLT3, or MLLT1.
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