小鼠胶质瘤的光动力疗法：颅内肿瘤具有抗性，而皮下肿瘤敏感。
Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.
作者信息
Lindsay E A, Berenbaum M C, Bonnett R, Thomas D G
机构信息
Department of Experimental Pathology, St Mary's Hospital Medical School, London, UK.
出版信息
Br J Cancer. 1991 Feb;63(2):242-6. doi: 10.1038/bjc.1991.57.
Abstract
Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of necrosis. Resistance of intracerebral tumours was not due to failure of the sensitiser to enter tumours. Necrosis of intracranial tumours was increased when mice breathed 100% oxygen during PDT while subcutaneous tumour necrosis was unaffected.
摘要
皮下和颅内VMDk肿瘤采用新型敏化剂m-THPP进行光动力疗法（PDT）治疗。皮下肿瘤对PDT高度敏感，但颅内肿瘤的耐药性要强得多，需要将敏化剂剂量增加30倍才能产生同等程度的坏死。脑内肿瘤的耐药性并非由于敏化剂未能进入肿瘤。在PDT期间让小鼠呼吸100%氧气时，颅内肿瘤的坏死增加，而皮下肿瘤的坏死不受影响。
相似文献
1
Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.小鼠胶质瘤的光动力疗法：颅内肿瘤具有抗性，而皮下肿瘤敏感。
Br J Cancer. 1991 Feb;63(2):242-6. doi: 10.1038/bjc.1991.57.
2
Evaluation of porphyrin C analogues for photodynamic therapy of cerebral glioma.用于脑胶质瘤光动力治疗的卟啉C类似物的评估
Br J Cancer. 1996 Feb;73(4):514-21. doi: 10.1038/bjc.1996.89.
3
4
Concomitant treatment with temozolomide enhances apoptotic cell death in glioma cells induced by photodynamic therapy with talaporfin sodium.替莫唑胺联合治疗增强了钠他拉滨光动力疗法诱导的脑胶质瘤细胞的细胞凋亡。
Photodiagnosis Photodyn Ther. 2014 Dec;11(4):556-64. doi: 10.1016/j.pdpdt.2014.09.002. Epub 2014 Sep 28.
5
Subclinical photodynamic therapy treatment modifies the brain microenvironment and promotes glioma growth.亚临床光动力疗法治疗会改变脑微环境并促进胶质瘤生长。
Glia. 2007 Aug 1;55(10):1053-60. doi: 10.1002/glia.20525.
6
Photodynamic Therapy in Adult Intra-axial Brain Tumours.光动力疗法治疗成人脑内轴内肿瘤。
J Pak Med Assoc. 2024 Feb;74(2):404-406. doi: 10.47391/JPMA.24-11.
7
Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion.用光动力疗法使裸鼠脑组织致敏可诱导ADAM17/TACE并促进胶质瘤细胞侵袭。
Cancer Lett. 2008 Jul 8;265(2):177-87. doi: 10.1016/j.canlet.2008.02.023. Epub 2008 Mar 20.
8
Preclinical evaluation of benzoporphyrin derivative combined with a light-emitting diode array for photodynamic therapy of brain tumors.苯并卟啉衍生物联合发光二极管阵列用于脑肿瘤光动力治疗的临床前评估
Pediatr Neurosurg. 1999 May;30(5):225-31. doi: 10.1159/000028802.
9
Combination of photodynamic therapy and temozolomide on glioma in a rat C6 glioma model.光动力疗法联合替莫唑胺治疗大鼠 C6 脑胶质瘤模型中的胶质瘤。
Photodiagnosis Photodyn Ther. 2014 Dec;11(4):603-12. doi: 10.1016/j.pdpdt.2014.10.007. Epub 2014 Nov 4.
10
Efficacy against subcutaneous or intracranial murine GL261 gliomas in relation to the concentration of the vascular-disrupting agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), in the brain and plasma.抗皮下或颅内 GL261 脑胶质瘤的疗效与脑和血浆中血管破坏剂 5,6-二甲基黄嘌呤-4-乙酸（DMXAA）的浓度有关。
Cancer Chemother Pharmacol. 2014 Mar;73(3):639-49. doi: 10.1007/s00280-014-2395-y. Epub 2014 Jan 30.
引用本文的文献
1
Subcutaneous Xenograft Models for Studying PDT In Vivo.皮下异种移植模型用于研究 PDT 体内。
Methods Mol Biol. 2022;2451:127-149. doi: 10.1007/978-1-0716-2099-1_10.
2
Animal models for photodynamic therapy (PDT).光动力疗法（PDT）的动物模型
Biosci Rep. 2015 Sep 28;35(6):e00265. doi: 10.1042/BSR20150188.
3
The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy.正常脑组织和颅内植入VX2肿瘤对间质光动力疗法的敏感性。
Br J Cancer. 1996 Feb;73(3):332-43. doi: 10.1038/bjc.1996.58.
本文引用的文献
1
Photoradiation therapy in the treatment of malignant brain tumors: a phase I (feasibility) study.光辐射疗法治疗恶性脑肿瘤：一项I期（可行性）研究。
Neurosurgery. 1981 Dec;9(6):672-8. doi: 10.1227/00006123-198112000-00010.
2
3
Optical properties of human brain.人类大脑的光学特性。
Photochem Photobiol. 1983 Sep;38(3):293-9. doi: 10.1111/j.1751-1097.1983.tb02674.x.
4
In vivo biological activity of the components of haematoporphyrin derivative.血卟啉衍生物各成分的体内生物活性。
Br J Cancer. 1982 Apr;45(4):571-81. doi: 10.1038/bjc.1982.94.
5
Fast attempts at the photodynamic treatment of human gliomas.人类神经胶质瘤光动力治疗的快速尝试。
J Neurosurg Sci. 1980 Jul-Dec;24(3-4):119-29.
6
Survival in glioblastoma: historical perspective.
Neurosurgery. 1980 Nov;7(5):435-9. doi: 10.1227/00006123-198011000-00001.
7
Acute skin response in albino mice following porphyrin photosensitization under oxic and anoxic conditions.白化小鼠在有氧和无氧条件下卟啉光敏化后的急性皮肤反应。
Photochem Photobiol. 1984 Oct;40(4):435-9. doi: 10.1111/j.1751-1097.1984.tb04614.x.
8
Oxygen dependency of photocytotoxicity with haematoporphyrin derivative.血卟啉衍生物光细胞毒性的氧依赖性
Photochem Photobiol. 1984 May;39(5):631-4. doi: 10.1111/j.1751-1097.1984.tb03902.x.
9
Astrocytomas in an inbred mouse strain.近交系小鼠品系中的星形细胞瘤
J Pathol. 1971 Apr;103(4):266-70. doi: 10.1002/path.1711030410.
10
Optical penetration in human intracranial tumors.光学在人类颅内肿瘤中的穿透情况。
Photochem Photobiol. 1985 Jan;41(1):73-6. doi: 10.1111/j.1751-1097.1985.tb03450.x.
Zotero 插件