Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Faculty of Medicine, Monash University, Clayton, Victoria 3800, Australia.
Sci Signal. 2009 Dec 8;2(100):jc2. doi: 10.1126/scisignal.2100jc2.
Maturation of T cells in the thymus involves input from a number of signaling pathways; their combined input determines whether thymic precursor cells will differentiate into mature alphabeta or gammadelta T cells. This Journal Club article highlights recent research showing that the role of Notch signaling in human T cell maturation differs from that in mice. In mice, reducing Notch gene dosage in vivo promotes gammadelta T cell differentiation. In humans, an increase in Notch activity early in development will trigger gammadelta T cell development. This research emphasizes how the molecular events controlling T cell development are fundamentally different in humans and mice.
胸腺中 T 细胞的成熟涉及到许多信号通路的输入；它们的综合输入决定了胸腺前体细胞是否会分化为成熟的αβ或γδ T 细胞。这篇期刊俱乐部文章强调了最近的研究表明，Notch 信号在人类 T 细胞成熟中的作用与在小鼠中不同。在小鼠中，体内降低 Notch 基因剂量会促进γδ T 细胞分化。在人类中，早期发育中 Notch 活性的增加会引发γδ T 细胞的发育。这项研究强调了控制 T 细胞发育的分子事件在人类和小鼠中是如何存在根本差异的。
Zotero 插件