Dermatology Department, Hospital Clinic, IDIBAPS, CIBER de enfermedades raras, Barcelona, Spain.
Dermatology. 2010;220(1):66-70. doi: 10.1159/000264670. Epub 2009 Dec 4.
Juvenile xanthogranuloma in adulthood is an infrequent non-Langerhans cell histiocytosis, which may simulate malignant tumors such as basal cell carcinoma (BCC) or amelanotic melanoma. Dermoscopy has been described as a useful tool in the preoperative diagnosis of xanthogranuloma. We report a xanthogranuloma on the suprapubic area of a 48-year-old female, which clinically and dermoscopically mimicked a BCC with a yellowish hue and arborizing vessels. Reflectance confocal microscopy exhibited large highly refractive atypical cells in the dermis, some of them with pleomorphic nuclei, corresponding to Touton cells in the histopathological study. To our knowledge this is the first description of the clinical, dermoscopic and confocal microscopy correlations of a xanthogranuloma.
成人幼年黄色肉芽肿是一种罕见的非朗格汉斯细胞组织细胞增生症,它可能类似于基底细胞癌(BCC)或无黑色素性黑素瘤等恶性肿瘤。皮肤镜检查已被描述为黄色肉芽肿术前诊断的有用工具。我们报告了一例发生于 48 岁女性耻骨区的黄色肉芽肿,其临床表现和皮肤镜下表现类似于 BCC,具有黄色色调和树枝状血管。反射共聚焦显微镜显示真皮中有大量大而高折光的非典型细胞,其中一些具有多形性核,与组织病理学研究中的 Touton 细胞相对应。据我们所知,这是首例描述黄色肉芽肿的临床、皮肤镜和共聚焦显微镜相关性的病例。