INSERM UMRS 940, Equipe Avenir, Université Paris 7, Institut de Génétique Moléculaire, 75010 Paris, France.
Expert Opin Ther Targets. 2010 Jan;14(1):57-65. doi: 10.1517/14728220903431077.
Since its discovery in 1997, the antiapoptotic factor AAC-11 has rapidly gained attention due to its potential use in cancer therapy. Indeed, most cancer cells express elevated levels of AAC-11, which is now known to be involved in both tumor cells growth as well as sensitivity to chemotherapeutic drugs.
In this review, we examine the most recent evidence about the role of AAC-11 in cancer biology and the therapeutic perspectives associated with its specific targeting. For that purpose, literature dealing with AAC-11 in the PubMed database was reviewed from 1997 up to date.
AAC-11 is an antiapoptotic gene that has the potential to be a target for anti-cancer therapy, and warrants further investigation. As its expression seems to predict unfavorable prognosis, at least in some cancers, it also may become a potent prognostic marker.
Blocking AAC-11 function in cancer for therapeutic purposes might be of great interest. The recent report of efficient AAC-11 inhibiting peptides that sensitize tumor cells to chemotherapeutic drugs has raise the exciting notion that AAC-11 might be a druggable target and fueled the search for new therapeutic agents that could block AAC-11 function.
自 1997 年发现以来，由于其在癌症治疗中的潜在用途，抗凋亡因子 AAC-11 迅速引起了关注。事实上，大多数癌细胞表达高水平的 AAC-11，现在已知它参与肿瘤细胞的生长以及对化疗药物的敏感性。
在这篇综述中，我们检查了关于 AAC-11 在癌症生物学中的作用的最新证据以及与其特定靶向相关的治疗前景。为此，从 1997 年至今，在 PubMed 数据库中查阅了有关 AAC-11 的文献。
AAC-11 是一种抗凋亡基因，有可能成为抗癌治疗的靶点，值得进一步研究。由于其表达似乎预测预后不良，至少在某些癌症中是这样，因此它也可能成为一种有效的预后标志物。
出于治疗目的阻断癌症中的 AAC-11 功能可能非常有趣。最近有报道称，有效的 AAC-11 抑制肽可使肿瘤细胞对化疗药物敏感，这一令人兴奋的观点认为，AAC-11 可能是一个可用药的靶点，并促使人们寻找新的治疗剂来阻断 AAC-11 的功能。
