丹麦 1995-2004 年鼻腔和鼻窦癌。

Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004.

机构信息

Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

Acta Oncol. 2010 Apr;49(3):389-94. doi: 10.3109/02841860903428176.

DOI:10.3109/02841860903428176

PMID:20001493

Abstract

OBJECTIVE

To evaluate the treatment outcome for sino-nasal carcinomas in Denmark from 1995-2004 and compare the results to the previous Danish survey covering 1982-1991.

DESIGN

Retrospective follow-up.

MATERIALS AND METHODS

In the five Danish head and neck oncology centres, charts of all consecutive patients with sino-nasal carcinomas were reviewed and data extracted to a common database. Altogether 242 patients from the period 1995-2004 were identified. Of these 162 (67%) were male and 80 (33%) female. Histologies included squamous cell carcinoma (55%), adenocarcinoma (28.5%), adenoid-cystic carcinoma (5.0%), undifferentiated carcinoma (4.5%), transitiocellular carcinoma (1.7%), mucoepidermoid carcinoma (0.8%), neuroendocrine carcinoma (2.5%), small cell carcinomas (1.2%) and carcinomas not otherwise specified (0.8%). Treatments included radiotherapy alone 79 (33%), surgery alone 29 (12%), combined surgery and radiotherapy 96 (40%), palliative/no treatment 38 (16%). A total of 204 (86%) patients were treated with curative intent.

RESULTS

Of the 204 patients treated with curative intent, 94 (46%) relapsed. Most failures were in T-site (63, 30%). N-site failures were 10 (5%) and M-site failures six (3%). Failure occurring in T+N-site, T+M-site, N+M-site and T+N+M-site were seven (3%), two (1%), one (0.5%) and five (3%) respectively. The 5-year actuarial local, nodal and loco-regional control rates were 55 + or - 4%, 86 + or - 3%, 49 + or - 4%, respectively. The overall 5-year actuarial survival rate for the entire cohort was 47 + or - 3%, and the corresponding cancer-specific 5-year actuarial survival rate was 57 + or - 3%. Female gender, nasal cavity tumour, adenocarcinoma and low clinical stage were significant positive prognostic factors in univariate analysis. A Cox multivariate analysis showed that only tumour site and clinical stage were independent significant prognostic factors.

CONCLUSION

The current series has confirmed stage and tumour site as independent prognostic factors. Compared to the previous Danish survey covering the period 1982-1991, the overall survival and cancer-specific survival rates have improved significantly.

摘要

目的

评估丹麦 1995-2004 年期间鼻窦癌的治疗结果，并与 1982-1991 年丹麦的前一次调查结果进行比较。

设计

回顾性随访。

材料和方法

在丹麦的 5 个头颈部肿瘤中心，对所有连续的鼻窦癌患者的病历进行了回顾，并将数据提取到一个共同的数据库中。共确定了 1995-2004 年期间的 242 例患者。其中 162 例（67%）为男性，80 例（33%）为女性。组织学包括鳞状细胞癌（55%）、腺癌（28.5%）、腺样囊性癌（5.0%）、未分化癌（4.5%）、移行细胞癌（1.7%）、黏液表皮样癌（0.8%）、神经内分泌癌（2.5%）、小细胞癌（1.2%）和其他未特指的癌（0.8%）。治疗方法包括单纯放疗 79 例（33%）、单纯手术 29 例（12%）、手术联合放疗 96 例（40%）、姑息治疗/未治疗 38 例（16%）。共有 204 例（86%）患者接受了根治性治疗。

结果

204 例接受根治性治疗的患者中，94 例（46%）复发。大多数失败发生在 T 部位（63 例，30%）。N 部位失败 10 例（5%），M 部位失败 6 例（3%）。T+N 部位、T+M 部位、N+M 部位和 T+N+M 部位的失败分别为 7 例（3%）、2 例（1%）、1 例（0.5%）和 5 例（3%）。局部、淋巴结和局部区域的 5 年累积控制率分别为 55+/-4%、86+/-3%和 49+/-4%。整个队列的 5 年总生存率为 47+/-3%，相应的癌症特异性 5 年总生存率为 57+/-3%。女性、鼻腔肿瘤、腺癌和低临床分期是单因素分析中的显著正预后因素。Cox 多因素分析显示，只有肿瘤部位和临床分期是独立的显著预后因素。