Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Acta Oncol. 2010;49(2):180-4. doi: 10.3109/02841860903386390.
We studied variation in incidence of cervix cancer during 1971-1995 among Finnish women born in 1906 to 1945 by social class and cell type.
The Finnish Cancer Registry data were linked to the 1970 Population Census, which included social class data. There were 0.8 million individuals in the cohort under follow-up, with 5,102 squamous cell cancers and 573 cases of cervical adenocarcinoma diagnosed after the census date.
Incidence of squamous cell cancer was more than two-fold in the lowest social class (standardized incidence ratio (SIR) 1.29, 95% CI 1.21-1.36) as compared with the highest one (SIR 0.59, 0.51-0.66), while there was no association between social class and risk on adenocarcinoma (SIR 1.07, 0.87-1.28 and 1.08, 0.79-1.45, respectively).
Oncogenic HPV is regarded as the necessary cause of all types of cervix cancer. Sexually transmitted diseases and social status are correlated. Lack of association between adenocarcinoma and social class makes the HPV-etiology of this cell type less credible than that of squamous cell cancer.
我们研究了 1971 年至 1995 年期间芬兰女性宫颈癌发病率的变化，这些女性出生于 1906 年至 1945 年，按社会阶层和细胞类型划分。
芬兰癌症登记处的数据与 1970 年人口普查相联系，其中包括社会阶层数据。在随访队列中有 80 万人，在人口普查日期后诊断出 5102 例鳞状细胞癌和 573 例宫颈腺癌病例。
与最高社会阶层相比（标准化发病比（SIR）为 0.59，95%置信区间为 0.51-0.66），最低社会阶层的鳞状细胞癌发病率高出两倍以上（SIR 为 1.29，95%置信区间为 1.21-1.36），而腺癌与社会阶层之间没有关联（SIR 分别为 1.07、0.87-1.28 和 1.08、0.79-1.45）。
致癌 HPV 被认为是所有类型宫颈癌的必要病因。性传播疾病和社会地位是相关的。腺癌与社会阶层之间缺乏关联使得这种细胞类型的 HPV 病因学不如鳞状细胞癌可信。
