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肾和胰腺移植受者患者因卡氏枝孢霉引起的着色芽生菌病的不寻常表现,经泊沙康唑和手术切除成功治疗。

Unusual presentation of chromoblastomycosis due to Cladophialophora carrionii in a renal and pancreas transplant recipient patient successfully treated with posaconazole and surgical excision.

作者信息

Dupont C, Duong T A, Mallet S, Mamzer-Bruneel M F, Thervet E, Bougnoux M E, Dupont B

机构信息

Laboratoire de Parasitologie-Mycolgie, Université Paris Descartes, Paris, France.

出版信息

Transpl Infect Dis. 2010 Apr;12(2):180-3. doi: 10.1111/j.1399-3062.2009.00477.x. Epub 2009 Dec 7.

Abstract

Chromoblastomycosis is a chronic, tropical and subtropical, subcutaneous mycosis caused by inoculation of dematiaceous molds. This disease is uncommonly reported in patients who have undergone solid organ transplantation. We describe a case of chromoblastomycosis caused by Cladophialophora carrionii that occurred 7 years after transplantation in a 58-year-old male renal and pancreatic transplant recipient. Diagnosis was based on histopathology and isolation of multiple colonies of the dematiaceous mold in pure culture. Identification was achieved by sequencing of the internal transcribed spacer regions of the rRNA. The patient was successfully treated with posaconazole and surgical excision of a residual lesion.

摘要

着色芽生菌病是一种由暗色霉菌接种引起的慢性、热带和亚热带皮下真菌病。实体器官移植患者中很少报告这种疾病。我们描述了一例由卡氏枝孢瓶霉引起的着色芽生菌病,发生在一名58岁男性肾和胰腺移植受者移植后7年。诊断基于组织病理学和在纯培养中分离出多个暗色霉菌菌落。通过对rRNA的内部转录间隔区进行测序来实现鉴定。患者接受泊沙康唑治疗并成功切除残留病变。

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