Division of Endocrinology, Department of Pediatrics, University of Virginia Children's Hospital, Charlottesville, VA, USA.
BJOG. 2010 Jan;117(2):143-9. doi: 10.1111/j.1471-0528.2009.02383.x.
Polycystic ovarian syndrome is a common disorder characterized by ovulatory dysfunction and hyperandrogenemia (HA). Its origins begin peripubertally, as adolescent HA commonly leads to adult HA and decreased fertility. HA reduces inhibition of gonadotropin releasing hormone pulse frequency by progesterone, causing rapid LH pulse secretion and further increasing ovarian androgen production. Obese girls are at risk for HA and develop increased LH pulse frequency with elevated mean LH by late puberty. Many girls with HA do not exhibit normal LH pulse sensitivity to progesterone inhibition. Thus, HA may adversely affect LH pulse regulation during pubertal maturation leading to persistent HA.
多囊卵巢综合征是一种常见的疾病,其特征是排卵功能障碍和高雄激素血症(HA)。其起源始于青春期前,因为青少年 HA 通常会导致成年 HA 和生育能力下降。HA 降低了孕激素对促性腺激素释放激素脉冲频率的抑制作用,导致 LH 脉冲快速分泌,并进一步增加卵巢雄激素的产生。肥胖女孩有 HA 的风险,并且在青春期后期随着平均 LH 的升高而增加 LH 脉冲频率。许多有 HA 的女孩对孕激素抑制 LH 脉冲的敏感性并不正常。因此,HA 可能会在青春期成熟过程中对 LH 脉冲调节产生不利影响,导致持续的 HA。