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腹腔镜 Heller 肌切开术加 Dor 胃底折叠术治疗贲门失弛缓症:长期结果和对胸痛的影响。

Laparoscopic Heller myotomy with Dor fundoplication for achalasia: long-term outcomes and effect on chest pain.

机构信息

Department of Surgery, Iwate Medical University School of Medicine, Morioka, Japan.

出版信息

Dis Esophagus. 2010 May;23(4):284-9. doi: 10.1111/j.1442-2050.2009.01032.x. Epub 2009 Dec 11.

DOI:10.1111/j.1442-2050.2009.01032.x
PMID:20002700
Abstract

The aim of the present study was to evaluate the long-term outcomes of laparoscopic Heller myotomy with Dor fundoplication (LHD) and its effect on chest pain. Between June 1995 and August 2009, a total of 35 patients with achalasia underwent an LHD. The symptom scores were calculated by combining the frequency and the severity. Pre- and postoperative evaluations included symptom score, radiology, manometry, and 24-hour pH manometry. Median total symptom score was significantly lower than the preoperative score (19 vs 4, P < 0.001) at a median follow-up of 94 months. Among the 35 patients, 18 (51%) had chest pain. The frequency of chest pain was similar for the pre- and postoperative scores, but the severity tended to be less. Median esophageal diameter (5.4 cm vs 3.5 cm, P < 0.001) and lower esophageal sphincter pressure (41 mmHg vs 8.9 mmHg, P < 0.001) were significantly reduced after surgery. Median age, duration of symptoms, esophageal diameter, and lower esophageal sphincter pressure were similar between patients with and without chest pain prior to surgery. No significant differences were observed between the two groups in terms of amplitude, duration, and frequency of contractions from the findings of postoperative 24-hour esophageal manometry. Chest pain resolved in three patients (17%) and improved in seven patients (39%) after surgery. LHD can durably relieve achalasic symptoms of both dysphagia and regurgitation, and it can be considered the surgical procedure of choice. However, achalasic chest pain does not always seem to be related with patient characteristics and manometric findings.

摘要

本研究旨在评估腹腔镜 Heller 肌切开术加 Dor 胃底折叠术(LHD)的长期疗效及其对胸痛的影响。1995 年 6 月至 2009 年 8 月,共有 35 例贲门失弛缓症患者接受了 LHD。症状评分通过结合频率和严重程度进行计算。术前和术后评估包括症状评分、放射学、测压和 24 小时 pH 测压。中位总症状评分明显低于术前评分(19 分比 4 分,P<0.001),中位随访时间为 94 个月。在 35 例患者中,18 例(51%)有胸痛。胸痛的术前和术后评分频率相似,但严重程度较低。中位食管直径(5.4cm 比 3.5cm,P<0.001)和食管下括约肌压力(41mmHg 比 8.9mmHg,P<0.001)术后显著降低。术前胸痛患者的中位年龄、症状持续时间、食管直径和食管下括约肌压力与无胸痛患者相似。术后 24 小时食管测压发现两组之间的收缩幅度、持续时间和频率无显著差异。手术后,有 3 例患者(17%)胸痛缓解,7 例患者(39%)胸痛改善。LHD 可持久缓解吞咽困难和反流的贲门失弛缓症症状,可作为首选的手术方法。然而,贲门失弛缓症胸痛似乎并不总是与患者特征和测压结果有关。

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