Department of Disease Biology, University of Copenhagen, Denmark.
Br J Nutr. 2010 May;103(9):1251-9. doi: 10.1017/S0007114509993229. Epub 2009 Dec 15.
In contrast to the promised 'antioxidant miracle' of the 1980s, several randomised controlled trials have shown no effect of antioxidant supplements on hard endpoints such as morbidity and mortality. The former over-optimistic attitude has clearly called for a more realistic assessment of the benefit:harm ratio of antioxidant supplements. We have examined the literature on vitamin C intervention with the intention of drawing a conclusion on its possible beneficial or deleterious effect on health and the result is discouraging. One of several important issues is that vitamin C uptake is tightly controlled, resulting in a wide-ranging bioavailability depending on the current vitamin C status. Lack of proper selection criteria dominates the currently available literature. Thus, while supplementation with vitamin C is likely to be without effect for the majority of the Western population due to saturation through their normal diet, there could be a large subpopulation with a potential health problem that remains uninvestigated. The present review discusses the relevance of the available literature on vitamin C supplementation and proposes guidelines for future randomised intervention trials.
与 20 世纪 80 年代承诺的“抗氧化奇迹”相反，几项随机对照试验表明，抗氧化补充剂对发病率和死亡率等硬性终点没有影响。以前过于乐观的态度显然需要对抗氧化补充剂的获益与风险比进行更现实的评估。我们检查了关于维生素 C 干预的文献，旨在对其对健康的可能有益或有害影响得出结论，结果令人沮丧。几个重要问题之一是维生素 C 的摄取受到严格控制，导致根据当前的维生素 C 状态，生物利用度广泛变化。缺乏适当的选择标准主导着目前可用的文献。因此，由于通过正常饮食使大多数西方人群的维生素 C 达到饱和，补充维生素 C 可能对他们没有效果，但可能有一个潜在健康问题的大亚人群尚未得到调查。本综述讨论了现有关于维生素 C 补充的文献的相关性，并为未来的随机干预试验提出了指导方针。
