Department of Anatomy and Comparative Pathology, Faculty of Veterinary Medicine, Cordoba University, 14014 Cordoba, Spain.
Comp Immunol Microbiol Infect Dis. 2010 Dec;33(6):e51-8. doi: 10.1016/j.cimid.2009.11.003. Epub 2009 Dec 8.
This study was focused on the changes observed in the serum concentration of haptoglobin (Hp), C-reactive protein (CRP), serum amyloid A (SAA) and Pig-major acute protein (Pig-MAP), during experimental porcine reproductive and respiratory syndrome virus (PRRSV) infection and in their relationship with the expression of interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Hp and Pig-MAP serum levels were increased at 10 dpi, but CRP and SAA showed a delayed and highly variable increase. All three proinflammatory cytokines were poorly expressed, and only a mild increase in IL-1β was observed at 7 dpi. The increased expression of Hp coincided with the light enhancement observed in both IL-6 and TNF-α, and might be related with an increased expression of IL-10. The low expression of TNF-α might point to a possible mechanism of viral evasion of host-immune response. This issue and the delayed expression of CRP and SAA should be taken into account in future studies about modulation of the immune response by PRRSV infection.
本研究集中观察了实验性猪繁殖与呼吸综合征病毒（PRRSV）感染期间血清结合珠蛋白（Hp）、C 反应蛋白（CRP）、血清淀粉样蛋白 A（SAA）和主要急性猪蛋白（Pig-MAP）浓度的变化，及其与白细胞介素 1β（IL-1β）、白细胞介素 6（IL-6）和肿瘤坏死因子α（TNF-α）表达的关系。Hp 和 Pig-MAP 血清水平在 10dpi 时升高，但 CRP 和 SAA 表现出延迟和高度可变的增加。所有三种促炎细胞因子的表达都很差，只有在 7dpi 时观察到 IL-1β 的轻度增加。Hp 的表达增加与 IL-6 和 TNF-α 观察到的光增强相一致，可能与 IL-10 的表达增加有关。TNF-α 的低表达可能指向病毒逃避宿主免疫反应的可能机制。在未来关于 PRRSV 感染对免疫反应调节的研究中，应考虑到这一问题以及 CRP 和 SAA 的延迟表达。
