Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy.
Cytokine Growth Factor Rev. 2010 Feb;21(1):27-39. doi: 10.1016/j.cytogfr.2009.11.007. Epub 2009 Dec 8.
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways of tumor progression, including: leukocyte recruitment and function; cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.
趋化因子是癌症相关炎症的关键组成部分。趋化因子和趋化因子受体是导致肿瘤转化的遗传事件的下游产物，也是慢性炎症状态的组成部分，这种慢性炎症状态容易导致癌症。趋化因子系统的成分以细胞自主或非自主的方式影响肿瘤进展的多个途径，包括：白细胞募集和功能；细胞衰老；肿瘤细胞增殖和存活；侵袭和转移。临床前和临床环境中的现有信息表明，趋化因子系统代表了开发创新治疗策略的有价值的靶点。
