Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands.
J Cyst Fibros. 2010 Jan;9(1):59-63. doi: 10.1016/j.jcf.2009.11.003. Epub 2009 Dec 8.
The aims of this study were to determine prevalence, risk factors and treatment of constipation in patients with Cystic Fibrosis (CF), as well as the diagnostic value of abdominal radiography.
A cohort of 214 pediatric CF patients was investigated. Furthermore, 106 abdominal radiographs of CF patients with or without constipation were independently assessed by three observers on two separate occasions using the Barr and Leech scores.
The prevalence of constipation was 47%. Low total fat absorption and meconium ileus were independent risk factors for constipation in CF, while fiber and fluid intake were not associated. In CF patients the inter and intraobserver variabilities of the Barr and Leech scores were poor to moderate.
Constipation is a significant medical issue in CF and was associated with low total fat absorption and a history of meconium ileus. Finally, abdominal radiography seems of little value in the regular follow-up of CF patients.
本研究旨在确定囊性纤维化（CF）患者便秘的患病率、危险因素和治疗方法，以及腹部 X 光检查的诊断价值。
对 214 例儿科 CF 患者进行了队列研究。此外，还对 106 例伴有或不伴有便秘的 CF 患者的腹部 X 光片进行了独立评估，由 3 位观察者在两次不同的时间分别使用 Barr 和 Leech 评分进行评估。
便秘的患病率为 47%。总脂肪吸收不良和胎粪性肠梗阻是 CF 患者发生便秘的独立危险因素，而纤维和液体摄入与便秘无关。在 CF 患者中，Barr 和 Leech 评分的观察者间和观察者内变异性较差至中等。
便秘是 CF 的一个重要医学问题，与总脂肪吸收不良和胎粪性肠梗阻病史有关。最后，腹部 X 光检查在 CF 患者的常规随访中似乎没有价值。
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