B 淋巴细胞刺激因子-817C>T 启动子多态性与深部浸润型子宫内膜异位症易感性的关系。
B lymphocyte stimulator -817C>T promoter polymorphism and the predisposition for the development of deep infiltrating endometriosis.
机构信息
Department of Obstetrics and Gynecology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
出版信息
Fertil Steril. 2010 Aug;94(3):1108-10. doi: 10.1016/j.fertnstert.2009.10.041. Epub 2009 Dec 11.
The prevalence of the BLyS -817C>T polymorphic variant among women with either deep infiltrating endometriosis or adenomyosis compared with a group of gynecologic patients without symptomatic endometriosis and a group of healthy women was assessed in this study. Patients with deep infiltrating endometriosis had less often a BLyS -817C/T genotype as compared with the reference group, with an odds ratio of 0.50 (95% confidence interval 0.27-0.93 versus the C/C genotype).
本研究评估了患有深部浸润性子宫内膜异位症或子宫腺肌病的女性与无症状子宫内膜异位症的妇科患者组和健康女性组相比，BLyS-817C>T 多态性变异的流行率。与参考组相比，深部浸润性子宫内膜异位症患者的 BLyS-817C/T 基因型较少，比值比为 0.50（95%置信区间 0.27-0.93 与 C/C 基因型相比）。
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