在强迫症的模糊和风险情境下,决策的分离。
Dissociation of decisions in ambiguous and risky situations in obsessive-compulsive disorder.
机构信息
Department of Physiological Psychology, University of Bielefeld, P.O. Box 100131, 33501 Bielefeld, Germany.
出版信息
Psychiatry Res. 2010 Jan 30;175(1-2):114-20. doi: 10.1016/j.psychres.2008.10.022. Epub 2009 Dec 11.
Patients with obsessive-compulsive disorder (OCD) often show deficits in everyday decision-making, a phenomenon which is leading to a growing research interest in neuropsychological aspects of decision-making in OCD. Previous investigations of OCD patients demonstrated deficits in the Iowa Gambling Task (IGT), a decision-making task with implicit rules. Results were interpreted as reflecting orbitofrontal cortex dysfunctions observed in OCD. The aim of the present study is to investigate OCD patients' performance on the Game of Dice Task (GDT), a decision-making task with explicit and stable rules. For this purpose, 23 patients with OCD and 22 healthy comparison subjects were examined with the GDT and the IGT as well as with tests of executive functioning. While patients performed worse than comparison subjects on the IGT, they were unimpaired on the GDT and executive functioning tasks. Results further emphasize dysfunctions of the orbitofrontal cortex, but indicate intact functioning of the dorsolateral prefrontal cortex in patients with OCD.
强迫症(OCD)患者在日常决策中常常表现出缺陷,这一现象促使人们对 OCD 患者的神经心理学决策方面产生了越来越大的研究兴趣。先前对 OCD 患者的研究表明,他们在具有内隐规则的爱荷华赌博任务(IGT)中存在缺陷。研究结果解释为反映了 OCD 中观察到的眶额皮层功能障碍。本研究旨在调查 OCD 患者在具有明确和稳定规则的骰子游戏任务(GDT)中的表现。为此,对 23 名 OCD 患者和 22 名健康对照组进行了 GDT 和 IGT 以及执行功能测试。虽然患者在 IGT 上的表现逊于对照组,但他们在 GDT 和执行功能任务上没有受到影响。研究结果进一步强调了眶额皮层的功能障碍,但表明 OCD 患者的背外侧前额叶皮层功能正常。