Department of Neurosurgery, Sri Satya Sai Institute of Higher Medical Sciences, Bangalore, Karnataka 560066, India.
Pediatr Neurol. 2010 Jan;42(1):72-4. doi: 10.1016/j.pediatrneurol.2009.08.005.
Pituitary adenomas are extremely rare in prepubescent children. Most of these tumors are functioning adenomas, but can also present with vision disturbances and changes in body morphology. We discuss the presentation, management, and outcome of a giant, solid, invasive prolactinoma in a 7-year-old boy who presented with visual disturbances and gynecomastia. The child demonstrated significant improvement in vision and a reduction in size of the tumor after subtotal tumor decompression and treatment with oral bromocriptine for 4 months. Tumor decompression and oral dopamine agonist therapy comprise the accepted treatment for pediatric prolactinomas. To our knowledge, only two previous reports described a giant prolactinoma in a prepubescent child. The relevant literature on pediatric pituitary tumours and prolactinoma is reviewed.
垂体腺瘤在青春期前儿童中极为罕见。这些肿瘤大多数是功能性腺瘤，但也可表现为视力障碍和身体形态的改变。我们讨论了一例 7 岁男孩的巨大、实性、侵袭性泌乳素瘤的表现、治疗和结局，该男孩因视力障碍和乳腺发育就诊。该患儿在接受部分肿瘤减压和口服溴隐亭治疗 4 个月后，视力显著改善，肿瘤体积缩小。肿瘤减压和口服多巴胺激动剂治疗是儿科泌乳素瘤的公认治疗方法。据我们所知，仅有两份之前的报告描述了青春期前儿童的巨大泌乳素瘤。我们回顾了相关的儿科垂体肿瘤和泌乳素瘤文献。
