Department of Obstetrics and Gynecology, Madigan Army Medical Center, Tacoma, WA, USA.
Am J Obstet Gynecol. 2010 Feb;202(2):189.e1-5. doi: 10.1016/j.ajog.2009.10.861. Epub 2009 Dec 14.
The objective of the study was to determine whether pretreatment of fetal or maternal placental vasculature with 17-hydroxyprogesterone caproate (17-P) attenuates the vasoactive effect of the thromboxane mimetic U46619.
Two cotyledons were obtained from each placenta studied. For the first 5 placentas, the fetal artery of 1 cotyledon from each pair was infused with 17-P. After 30 minutes, a bolus dose of U46619 was administered to both cotyledons. An identical procedure was carried out on the next 5 placentas except that 17-P was infused into the intervillous space.
The pressure excursion caused by bolus administration of U46619 was less in the cotyledons infused with 17-P, both in the 5 cases in which the fetal vasculature was infused with 17-P (P = .0035) and in the 5 cases in which the maternal vasculature was infused with 17-P (P = .038).
Pretreatment of either the fetal or maternal circuits of the placenta with 17-P attenuates U46619-mediated fetoplacental vasoconstriction.
本研究旨在确定 17-羟孕酮己酸酯（17-P）预处理胎儿或母体胎盘血管是否能减轻血栓烷类似物 U46619 的血管活性作用。
从每个研究的胎盘获得两个绒毛叶。对于前 5 个胎盘，从每对胎盘的一个绒毛叶中输注 17-P。30 分钟后，向两个绒毛叶给予 U46619 负荷剂量。对下 5 个胎盘进行相同的处理，只是将 17-P 注入绒毛间隙。
在胎儿血管输注 17-P 的 5 个病例中（P =.0035）和在母体血管输注 17-P 的 5 个病例中（P =.038），U46619 负荷剂量引起的压力激增量在输注 17-P 的绒毛叶中较小。
用 17-P 预处理胎盘的胎儿或母体循环可减轻 U46619 介导的胎-胎盘血管收缩。
