Department of Oral and Maxillofacial Surgery, "Evangelismos" General Hospital, Dental School, University of Athens, Athens, Greece.
Int J Oral Maxillofac Surg. 2010 Mar;39(3):243-50. doi: 10.1016/j.ijom.2009.11.011. Epub 2009 Dec 14.
Tumors originating in the parapharyngeal space are rare; they comprise approximately 0.5% of head and neck tumors. Most (70-80%) are benign and the most frequent origins are salivary and neurogenic. The aim of this study is to present the surgical procedures used for the treatment of 13 patients with parapharyngeal space tumors; 11 of them were suffering from benign tumors (the most frequent being pleomorphic adenoma; 8 cases) and 2 from malignant lesions. The following surgical approaches were used: intraoral (2 cases), transcervical (4 cases) and transmandibular (7 cases) with different types of mandible osteotomies. The type of surgical approach was dictated by the type of the lesion (malignant or benign), the exact location, the size, the vascularity and the relation of the tumor to the neck neurovascular bundle. In all cases the selected surgical approach allowed the complete resection of the tumor, obtaining clear margins in cases of malignancy, without adding to the patient's preoperative morbidity. It was concluded that the surgical approach to the parapharyngeal space tumors must be adjusted to the tumor characteristics and be as wide is necessary to achieve its complete removal with safety.
发生于咽旁间隙的肿瘤罕见,占头颈部肿瘤的 0.5%左右。大多数(70-80%)为良性,最常见的起源是唾液腺和神经源性。本研究的目的是介绍我们治疗 13 例咽旁间隙肿瘤患者所采用的手术方法;其中 11 例为良性肿瘤(最常见的是多形性腺瘤,8 例),2 例为恶性病变。所采用的手术入路如下:经口(2 例)、经颈(4 例)和经下颌(7 例),采用不同类型的下颌骨切开术。手术入路的选择取决于病变的类型(良性或恶性)、确切位置、大小、血管分布以及肿瘤与颈部神经血管束的关系。在所有病例中,所选的手术入路均能完全切除肿瘤,对于恶性肿瘤获得明确的切缘,而不会增加患者术前的发病率。结论是,咽旁间隙肿瘤的手术入路必须根据肿瘤的特征进行调整,并尽可能广泛地进行,以安全地实现完全切除。