Department of Psychiatry, Academic Medical Centre, Amsterdam, Netherlands.
Eur Psychiatry. 2010 Mar;25(2):105-10. doi: 10.1016/j.eurpsy.2009.08.003. Epub 2009 Dec 14.
Neurocognitive abnormalities are prevalent in both first episode schizophrenia patients and in ultra high risk (UHR) patients.
To compare verbal fluency performance at baseline in UHR in patients that did and did not make the transition to psychosis.
Baseline verbal fluency performance in UHR-patients (n=47) was compared to match first episode patients (n=69) and normal controls (n=42).
Verbal fluency (semantic category) scores in UHR-patients did not differ significantly from the score in first episode schizophrenia patients. Both the UHR group (p<0.003) and the patient group (p<0.0001) performed significantly worse than controls. Compared to the non-transition group, the transition group performed worse on verbal fluency, semantic category (p<0.006) at baseline.
Verbal fluency (semantic category) is disturbed in UHR-patients that make the transition to psychosis and could contribute to an improved prediction of transition to psychosis in UHR-patients.
神经认知异常在首发精神分裂症患者和超高危 (UHR) 患者中都很常见。
比较 UHR 患者在向精神病过渡前后的基线时言语流畅性表现。
比较 UHR 患者（n=47）的基线言语流畅性表现与首发精神分裂症患者（n=69）和正常对照组（n=42）的表现。
UHR 患者的言语流畅性（语义类别）得分与首发精神分裂症患者的得分无显著差异。UHR 组（p<0.003）和患者组（p<0.0001）的得分均显著低于对照组。与非转化组相比，转化组在基线时言语流畅性、语义类别（p<0.006）上的表现更差。
向精神病过渡的 UHR 患者的言语流畅性（语义类别）受到干扰，这可能有助于提高对 UHR 患者向精神病过渡的预测。
