Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012, India.
J Magn Reson. 2010 Feb;202(2):217-22. doi: 10.1016/j.jmr.2009.11.009. Epub 2009 Nov 18.
We report the application of z-COSY experiment and a band selected version of it by employing a selective 90 degrees pulse entitled BASE-z-COSY for precise chiral discrimination, quantification of enantiomeric excess and the analyses of the (1)H NMR spectra of chiral molecules aligned in the chiral liquid crystalline solvent poly-gamma-benzyl-l-glutamate (PBLG). We have demonstrated their applicability for obtaining very high resolution in the (1)H NMR spectra of small organic molecules. It is well known that the commonly employed z-COSY experiment disentangles the spectral complexity, provides pure phase spectra with high resolution, aids in the complete spectral analyses, in addition to yielding information on relative signs of the couplings. The BASE-z-COSY experiment possesses all these properties, permits the measure of enantiomeric excess, in addition to large saving of instrument time.
我们报告了 z-COSY 实验及其带选择版本的应用，通过采用选择性 90 度脉冲（称为 BASE-z-COSY）进行精确的手性区分、对映过量的定量以及在手性液晶溶剂聚-gamma-苄基-l-谷氨酸（PBLG）中手性分子的（1）H NMR 光谱分析。我们已经证明了它们在获得小有机分子的（1）H NMR 光谱中非常高分辨率的适用性。众所周知，常用的 z-COSY 实验可解缠光谱复杂性，提供具有高分辨率的纯相光谱，有助于完整的光谱分析，以及提供关于耦合相对符号的信息。BASE-z-COSY 实验具有所有这些特性，允许测量对映过量，同时大大节省仪器时间。
