Apipan Benjamas, Rummasak Duangdee
Department of Surgery, Mahidol University Faculty of Dentistry, Bangkok, Thailand.
J Oral Maxillofac Surg. 2010 Jan;68(1):120-4. doi: 10.1016/j.joms.2009.07.065.
The present study sought to determine whether premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery.
A total of 60 patients undergoing bimaxillary surgery were studied in a prospective, randomized, and double-blind study of oral propranolol 10 mg or placebo as premedication before hypotensive anesthesia with sodium nitroprusside. Hemodynamic variables, the amount of sodium nitroprusside used, and blood loss were statistically analyzed.
The heart rate and amount of sodium nitroprusside used were highly significantly less (P < .01) in the propranolol group, but no significant difference was found in blood loss between the 2 groups. No clinically significant complications were observed in either group.
Premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside is safe and effective to reduce reflex tachycardia and the amount of sodium nitroprusside used.
本研究旨在确定在硝普钠降压麻醉前口服10毫克普萘洛尔进行预处理是否能减少正颌外科手术降压麻醉期间的反射性心动过速、硝普钠用量及失血量。
在一项前瞻性、随机、双盲研究中，对60例行双颌手术的患者在硝普钠降压麻醉前口服10毫克普萘洛尔或安慰剂进行预处理。对血流动力学变量、硝普钠用量及失血量进行统计学分析。
普萘洛尔组的心率和硝普钠用量显著低于（P <.01）对照组，但两组间失血量无显著差异。两组均未观察到具有临床意义的并发症。
在硝普钠降压麻醉前口服10毫克普萘洛尔进行预处理对减少反射性心动过速及硝普钠用量安全有效。
